Hochreiter, S., Younger, A.S., Conwell, P.R. Susanne Kimeswenger, Elisabeth Rumetshofer, Markus Hofmarcher, Philipp Tschandl, Harald Kittler, Sepp Hochreiter, Wolfram Hötzenecker, Günter Klambauer: Detecting cutaneous basal cell carcinomas in ultra-high resolution and weakly labelled histopathological images. Furthermore, host toxicity and adverse side effects are likely reduced, since doses of drug combinations are typically lower than doses of single agents (Chou, 2006; O’Neil et al., 2016). Sepp Hochreiter Fakult¨at f¨ur Informatik Technische Universit¨at M¨unchen 80290 M¨unchen, Germany hochreit@informatik.tu-muenchen.de Yoshua Bengio Dept. Author pages are created from data sourced from our academic publisher partnerships and public sources. In: Proceedings of the 32nd International Conference on Machine Learning (ICML), vol. Johannes Kepler University Linz, Austria. 836–843 (1989). The following articles are merged in Scholar. 2, pp. ECCV 2014. Uncertainty Fuzziness Knowl. 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CoRR abs/1911.06616 (2019) In: International Conference on Learning Representations (ICLR) (2014), Socher, R., et al. In: Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP), pp. Lapuschkin, S., Wäldchen, S., Binder, A., Montavon, G., Samek, W., Müller, K.R. ... Sepp Hochreiter Institute for Machine Learning, ... Douglas Eck Google Research, Brain Team Verified email at google.com. Pattern Recogn. In: Proceedings of the 55th Annual Meeting of the Association for Computational Linguistics (ACL), pp. IEEE Trans. 115–131. Greff, K., Srivastava, R.K., Koutník, J., Steunebrink, B.R., Schmidhuber, J.: LSTM: a search space odyssey. Widrow B, Hoff ME (1988) Adaptive switching circuits in 1960 ire wescon convention record, 1960. : Interpreting individual classifications of hierarchical networks. Shrikumar, A., Greenside, P., Kundaje, A.: Learning important features through propagating activation differences. Strateg. 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E Bonatesta, C Horejš-Kainrath, S Hochreiter. In: Proceedings of the 34th International Conference on Machine Learning (ICML), vol. Gers, F.A., Schmidhuber, J., Cummins, F.: Learning to forget: continual prediction with LSTM. In ACM SIGSPATIAL GIS, 2013. Over 10 million scientific documents at your fingertips. Sepp Hochreiter. How to learn, access, and retrieve such patterns is crucial in Hopfield networks and the more recent transformer architectures. In: Proceedings of the 34th International Conference on Machine Learning (ICML), vol. We compared several CNNs trained directly on high-throughput imaging data to the current state-of-the-art: fully connected networks trained on precalculated morphological cell features. Becker, S., Ackermann, M., Lapuschkin, S., Müller, K.R., Samek, W.: Interpreting and explaining deep neural networks for classification of audio signals. Lapuschkin, S., Binder, A., Montavon, G., Müller, K.R., Samek, W.: The LRP toolbox for artificial neural networks. 818–833. In: Proceedings of the EMNLP 2017 Workshop on Computational Approaches to Subjectivity, Sentiment and Social Media Analysis (WASSA), pp. Journal of chemical information and modeling. Centre-Ville, Montr´eal, Qu´ebec, Canada, H3C 3J7 bengioy@iro.umontreal.ca Paolo Frasconi Graves, A., Liwicki, M., Fernandez, S., Bertolami, R., Bunke, H., Schmidhuber, J.: A novel connectionist system for unconstrained handwriting recognition. A central mechanism in machine learning is to identify, store, and recognize patterns. Technical report, FKI-207-95, Fakultät für Informatik, Technische Universität München (1995), Hochreiter, S., Schmidhuber, J.: LSTM can solve hard long time lag problems. : Dynamic error propagation networks. Drug resistance can be decreased or even overcome through combination therapy (Huang et al., 2016; Kruijtzer et al., 2002; Tooker et al., 2007). Montavon, G., Samek, W., Müller, K.R. In Proceedings of the 4th International Conference on Learning Representations (ICLR). ... Sepp Hochreiter Institute for Machine Learning, ... Thomas Unterthiner Google Research (Brain Team) Verified email at bioinf.jku.at. Lundberg, S.M., Lee, S.I. pp 211-238 | Zeiler, M.D., Fergus, R.: Visualizing and understanding convolutional networks. 340–350. : Methods for interpreting and understanding deep neural networks. Rep. Kauffmann, J., Esders, M., Montavon, G., Samek, W., Müller, K.R.,: From clustering to cluster explanations via neural networks. A Field Guide to Dynamical Recurrent Networks, pp. Neural Netw. Prediction of human population responses to toxic compounds by a collaborative competition, The ability to computationally predict the effects of toxic compounds on humans could help address the deficiencies of current chemical safety testing. Pattern Anal. Res. This work was supported by the German Ministry for Education and Research as Berlin Big Data Centre (01IS14013A), Berlin Center for Machine Learning (01IS18037I) and TraMeExCo (01IS18056A). : Sequence to sequence learning with neural networks. Rev. Project leader of EU H2020 and Erasmus+ projects and of the FFG ASAP (Austrian Space Application Program) project ReKlaSat 3D - Deep Learning on Satellite Images and Satellite Image Point Cloud Reconstructions (2017-2019). Neural Networks. J. Mach. A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control consortium, We present primary results from the Sequencing Quality Control (SEQC) project, coordinated by the US Food and Drug Administration. Draft from November 2017, Thuillier, E., Gamper, H., Tashev, I.J. 3, pp. Experiments by Sepp Hochreiter. Large-scale comparison of machine learning methods for drug target prediction on ChEMBL† †Electronic supplementary information (ESI) available: Overview, Data Collection and Clustering, Methods. Association for Computational Linguistics (2018). Their combined citations are counted only for the first article. Google Scholar; Sepp Hochreiter and Jürgen Schmidhuber. Springer, Cham (2016). We introduce the "exponential linear unit" (ELU) which speeds up learning in deep neural networks and leads to higher classification accuracies. (eds.) Sahni, H.: Reinforcement learning never worked, and ‘deep’ only helped a bit. Schmidhuber, J.: Making the world differentiable: on using fully recurrent self-supervised neural networks for dynamic reinforcement learning and planning in non-stationary environments. In: Proceedings of the 35th International Conference on Machine Learning (ICML), vol. 70, pp. 1928–1937 (2016), Montavon, G., Binder, A., Lapuschkin, S., Samek, W., Müller, K.-R.: Layer-wise relevance propagation: an overview. Intell. 543–559. Zaremba, W., Sutskever, I., Vinyals, O.: Recurrent neural network regularization. In: IEEE International Conference on Computer Vision Workshops, pp. The new wave of successful generative models in machine learning has increased the interest in deep learning driven de novo drug design. Ecol. The following articles are merged in Scholar. ... Sepp Hochreiter . In: Proceedings of the ACL 2019 Workshop on BlackboxNLP: Analyzing and Interpreting Neural Networks for NLP, pp. : Learning to learn using gradient descent. 2006. J. Neurosci. High-throughput immunosequencing allows reconstructing the immune repertoire of an individual, which is an exceptional opportunity for new immunotherapies, immunodiagnostics, and vaccine design. In: Freksa, C. 338–342 (2014). Here, we report the results from a. Fréchet ChemNet Distance: A Metric for Generative Models for Molecules in Drug Discovery. In this chapter, we explore how to adapt the Layer-wise Relevance Propagation (LRP) technique used for explaining the predictions of feed-forward networks to the LSTM architecture used for sequential data modeling and forecasting. Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures. Li, J., Chen, X., Hovy, E., Jurafsky, D.: Visualizing and understanding neural models in NLP. Therefore, drug com… 80, pp. 9908, pp. 2017-0-00451, No. Learn. In: Kolen, J.F., Kremer, S.C. Jürgen Schmidhuber . Robinson, A.J. PLoS ONE, Arras, L., Montavon, G., Müller, K.R., Samek, W.: Explaining recurrent neural network predictions in sentiment analysis. 473–479 (1996). : Recursive deep models for semantic compositionality over a sentiment treebank. Methods, Sundararajan, M., Taly, A., Yan, Q.: Axiomatic attribution for deep networks. IEEE Press, New York (2001), Hochreiter, S., Heusel, M., Obermayer, K.: Fast model-based protein homology detection without alignment. 843–852 (2015), Sturm, I., Lapuschkin, S., Samek, W., Müller, K.R. Rahmandad, H., Repenning, N., Sterman, J.: Effects of feedback delay on learning. Luoma, J., Ruutu, S., King, A.W., Tikkanen, H.: Time delays, competitive interdependence, and firm performance. While neural networks have acted as a strong unifying force in the design of modern AI systems, the neural network architectures themselves remain highly heterogeneous due to the variety of tasks to be solved. Association for Computational Linguistics (2013), Srivastava, N., Mansimov, E., Salakhudinov, R.: Unsupervised learning of video representations using LSTMs. Most Cited: Google Scholar. In: AAAI Fall Symposium Series - Sequential Decision Making for Intelligent Agents, pp. 127–134 (2007). In: Leibe, B., Matas, J., Sebe, N., Welling, M. in PNAS (1) is pivotal, because it shows that an initial data filter can appropriately increase the detection power of a high-throughput experiment. Machine Learning Deep Learning Artificial Intelligence Neural Networks Bioinformatics. : Explaining therapy predictions with layer-wise relevance propagation in neural networks. IEEE Trans. Syst. 189–194 (2000), Gers, F.A., Schmidhuber, J., Cummins, F.: Learning to forget: continual prediction with LSTM. Such immune repertoires are shaped by past and current immune events, for example infection and disease, and thus record an individual's state of health. Not affiliated : Evaluating the visualization of what a deep neural network has learned. Sci. Fast and accurate deep network learning by exponential linear units (ELUs). IEEE Trans. Practical work, Institut für Informatik, Technische Universität München (1990), Hochreiter, S.: Untersuchungen zu dynamischen neuronalen Netzen. Morcos, A.S., Barrett, D.G., Rabinowitz, N.C., Botvinick, M.: On the importance of single directions for generalization. TSSCML, pp. Cite as. (eds.) Friedrich Schneider. Experiments by Sepp Hochreiter Google Scholar L. Arras and J. Arjona-Medina—Contributed equally to this work. Official J. Eur. Ding, Y., Liu, Y., Luan, H., Sun, M.: Visualizing and understanding neural machine translation. Bioinformatics, Hochreiter, S., Schmidhuber, J.: Long short-term memory. 48, pp. In: Proceedings of the International Conference on Artificial Neural Networks (ICANN), vol. Arjona-Medina, J.A., Gillhofer, M., Widrich, M., Unterthiner, T., Brandstetter, J., Hochreiter, S.: RUDDER: return decomposition for delayed rewards. 1724–1734. 32–38 (2013). In: IEEE Symposium on Computational Intelligence and Data Mining (CIDM), pp. : Unmasking clever hans predictors and assessing what machines really learn. (eds.) LNCS, vol. 152–162 (2018). 2017-0-01779). 113–126. Explainable AI, LNCS 11700, pp. 1475–1482 (2002), Bakker, B.: Reinforcement learning by backpropagation through an LSTM model/ critic. Search across a wide variety of disciplines and sources: articles, theses, books, abstracts and court opinions. In the case of the ubiquitous coiled-coil motif, structure and occurrence have been. Explainable AI: Interpreting, Explaining and Visualizing Deep Learning, https://doi.org/10.1007/978-3-319-98131-4_5, himanshusahni.github.io/2018/02/23/reinforcement-learning-never-worked.html, https://doi.org/10.1007/978-3-319-10590-1_53, https://doi.org/10.1007/978-3-319-46493-0_33, https://doi.org/10.1007/978-3-030-28954-6_11. 87–94 (2001). In: Advances in Neural Information Processing Systems 30 (NIPS), pp. In: International Conference on Learning Representations (ICLR) (2018), Munro, P.: A dual back-propagation scheme for scalar reward learning. 29–37 (2015). LNCS, vol. 69.167.175.221. Hochreiter, S., Schmidhuber, J.: Long short-term memory. 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